Peb siv cov ncuav qab zib los txhim kho koj qhov kev paub. Los ntawm kev txuas ntxiv mus saib lub vev xaib no, koj pom zoo rau peb siv cov ncuav qab zib. Xav paub ntxiv.
Los ntawm txhaj "Tswj Txhua", koj pom zoo rau kev khaws cov ncuav qab zib ntawm koj lub cuab yeej los txhim kho qhov chaw navigation, txheeb xyuas qhov chaw siv, thiab txhawb nqa peb qhov kev pub dawb, qhib nkag mus rau cov ntsiab lus tshawb fawb. Xav paub ntxiv.
Hauv kev tshawb fawb tsis ntev los no tau luam tawm nyob rau hauv phau ntawv Journal Pharmaceutics, cov kws tshawb fawb tau txiav txim siab txog kev siv tshuaj tua kab mob ntawm cov tshuaj ntsuab hu ua FRO tiv thaiv pob txuv pathogenesis.
Kev ntsuam xyuas tshuaj tua kab mob thiab hauv vitro tsom xam pom tias FRO muaj cov kab mob tseem ceeb thiab tiv thaiv kab mob tiv thaiv Dermatobacillus Acnes (CA), cov kab mob uas ua rau pob txuv. Cov txiaj ntsig no qhia tau tias nws muaj kev nyab xeeb thiab siv ntuj tsim hauv kev kho kom zoo nkauj ntawm pob txuv, txhawb kev siv cov tshuaj tsis muaj tshuaj lom thiab raug nqi rau cov tshuaj pob txuv tam sim no.
Txoj kev tshawb no: Kev ua tau zoo ntawm FRO nyob rau hauv pathogenesis ntawm pob txuv vulgaris. Duab credit: Steve Jungs / Shutterstock.com
Pob txuv vulgaris, feem ntau hu ua pob txuv, yog ib qho mob ntawm daim tawv nqaij uas tshwm sim los ntawm clogged plaub hau follicles nrog sebum thiab cov tawv nqaij tuag. Pob txuv cuam tshuam ntau dua 80 feem pua ​​​​ntawm cov tub ntxhais hluas thiab, txawm tias tsis ua rau tuag taus, tuaj yeem ua rau muaj kev ntxhov siab thiab, thaum mob hnyav, tawv nqaij pigmentation thiab caws pliav.
Cov pob txuv tshwm sim los ntawm kev sib cuam tshuam ntawm caj ces thiab ib puag ncig, feem ntau tshwm sim los ntawm kev hloov pauv hormonal uas nrog rau kev puberty thaum puberty. Cov hormonal imbalances no nce sebum ntau lawm thiab nce insulin loj hlob yam 1 (IGF-1) thiab dihydrotestosterone (DHT) kev ua.
Kev nce sebum secretion yog suav tias yog thawj theem ntawm kev txhim kho pob txuv, txij li cov hauv paus plaub hau saturated nrog sebum muaj ntau cov kab mob xws li SA. SA yog ib yam khoom muaj txiaj ntsig zoo ntawm daim tawv nqaij; Txawm li cas los xij, nce kev loj hlob ntawm nws cov phylotype IA1 ua rau mob thiab pigmentation ntawm cov hauv paus plaub hau nrog cov papules sab nraud.
Muaj ntau yam kev kho kom zoo nkauj rau pob txuv, xws li retinoids thiab tshuaj tua kab mob microbial, siv ua ke nrog tshuaj peels, laser / lub teeb kho, thiab cov tshuaj hormonal. Txawm li cas los xij, cov kev kho mob no kuj kim heev thiab cuam tshuam nrog kev phiv tsis zoo.
Cov kev tshawb fawb yav dhau los tau tshawb nrhiav tshuaj ntsuab rho tawm los ua ib qho txiaj ntsig zoo rau cov kev kho mob no. Raws li lwm txoj hauv kev, Rhus vulgaris (RV) extracts tau kawm. Txawm li cas los xij, nws txoj kev siv yog txwv los ntawm urushiol, ib qho tseem ceeb ua xua ntawm tsob ntoo no.
FRO yog ib hom tshuaj ntsuab uas muaj fermented extracts ntawm RV (FRV) thiab Japanese mangosteen (OJ) nyob rau hauv ib tug ratio ntawm 1: 1. Cov txiaj ntsig ntawm cov mis tau raug sim siv hauv vitro kev soj ntsuam thiab cov khoom siv tshuaj tua kab mob.
FRO sib tov yog thawj tus cwj pwm siv kev ua haujlwm siab ua kua chromatography (HPLC) los cais, txheeb xyuas thiab ntsuas nws cov khoom. Qhov sib tov tau raug tshuaj xyuas ntxiv rau tag nrho cov ntsiab lus phenolic (TPC) txhawm rau txheeb xyuas cov tebchaw feem ntau yuav muaj cov tshuaj tua kab mob.
Ua ntej hauv vitro antimicrobial assay los ntawm kev ntsuam xyuas disc diffusion rhiab heev. Ua ntej, CA (phylotype IA1) tau coj mus rau ib qho kev coj noj coj ua ntawm lub phaj agar uas tau muab tso rau ntawm 10 mm inch FRO-impregnated filter paper disk. Antimicrobial kev ua haujlwm tau soj ntsuam los ntawm kev ntsuas qhov loj ntawm thaj tsam inhibitory.
Kev ua tau zoo ntawm FRO ntawm CA-induced sebum ntau lawm thiab DHT-txuas nrog androgen surges tau soj ntsuam siv Roj Liab staining thiab Western blot tsom xam, feem. Tom qab ntawd FRO tau sim nws lub peev xwm los cuam tshuam cov teebmeem ntawm cov pa oxygen reactive (ROS), uas yog lub luag haujlwm rau pob txuv txuam nrog hyperpigmentation thiab cov nti tom qab phais, siv 2′,7′-dichlorofluorescein diacetate (DCF-DA) sojntsuam. ua rau.
Cov txiaj ntsig ntawm qhov kev sim disk diffusion pom tias 20 μL ntawm FRO tau ua tiav inhibit CA kev loj hlob thiab ua kom pom tseeb inhibition cheeb tsam ntawm 13 hli ntawm qhov concentration ntawm 100 mg / mL. FRO cuam tshuam qhov nce ntawm sebum secretion los ntawm SA, yog li ua kom qeeb lossis thim rov qab qhov tshwm sim ntawm pob txuv.
FRO tau pom tias muaj nplua nuj nyob hauv phenolic tebchaw nrog rau gallic acid, kaempferol, quercetin thiab fisetin. Tag nrho cov phenolic compound (TPC) concentration nruab nrab yog 118.2 mg gallic acid equivalents (GAE) ib gram FRO.
FRO txo qis cellular o tshwm sim los ntawm SA-induced ROS thiab cytokine tso tawm. Kev txo qis hauv ROS mus ntev tuaj yeem txo qis hyperpigmentation thiab caws pliav.
Txawm hais tias kev kho mob dermatological rau pob txuv muaj nyob, lawv feem ntau kim thiab tuaj yeem muaj ntau yam tsis xav tau.
Cov txiaj ntsig tau pom tias FRO muaj cov kab mob tua kab mob tiv thaiv CA (cov kab mob pob txuv ua rau pob txuv), yog li ua pov thawj tias FRO yog lub ntuj tsim, tsis muaj tshuaj lom thiab raug nqi rau kev kho pob txuv. FRO kuj txo qis sebum ntau lawm thiab cov tshuaj hormone qhia hauv vitro, ua kom pom nws cov txiaj ntsig hauv kev kho thiab tiv thaiv pob txuv flare-ups.
Yav dhau los FRO kev soj ntsuam kuaj pom tau hais tias cov neeg siv FRO's advanced toner thiab tshuaj pleev ib ce muaj kev txhim kho tseem ceeb ntawm daim tawv nqaij elasticity thiab noo noo theem piv rau pawg tswj tom qab tsuas yog rau lub lis piam. Txawm hais tias txoj kev tshawb no tsis tau ntsuas pob txuv nyob rau hauv kev tswj hwm hauv vitro, cov txiaj ntsig tam sim no txhawb lawv qhov kev tshawb pom.
Ua ke, cov txiaj ntsig no txhawb kev siv FRO yav tom ntej hauv kev kho kom zoo nkauj, suav nrog kev kho pob txuv thiab txhim kho tag nrho cov tawv nqaij noj qab haus huv.
Kab lus no tau hloov kho thaum Lub Rau Hli 9, 2023 los hloov cov duab tseem ceeb nrog qhov tsim nyog dua.
Muab tso rau hauv: Kev Kho Mob Xov Xwm | Xov xwm kho mob | Xov Xwm Kab Mob | Xov xwm kws tshuaj
Tags: pob txuv, cov hluas, androgens, anti-inflammatory, hlwb, chromatography, cytokines, dihydrotestosterone, kev ua tau zoo, fermentation, noob caj noob ces, loj hlob yam, plaub hau, tshuaj hormones, hyperpigmentation, in vitro, o, insulin, phototherapy, kua chromatography, oxygen, proliferation , quercetin, retinoids, tawv nqaij, tawv nqaij hlwb, tawv nqaij pigmentation, Western blot
Hugo Francisco de Souza yog tus kws sau ntawv tshawb fawb nyob hauv Bangalore, Karnataka, Is Nrias teb. Nws txoj kev kawm nyiam nyob rau hauv thaj chaw ntawm biogeography, evolutionary biology thiab herpetology. Tam sim no nws tab tom ua haujlwm ntawm nws daim ntawv pov thawj kws kho mob. los ntawm Center for Environmental Sciences ntawm Indian Institute of Science, qhov chaw nws kawm txog keeb kwm, kev faib tawm thiab speciation ntawm wetland nab. Hugo tau txais txiaj ntsig ntawm DST-INSPIRE Kev Sib Koom Tes rau nws cov kev tshawb fawb kws kho mob thiab tau txais txiaj ntsig kub los ntawm Pondicherry University rau nws txoj kev kawm tiav thaum nws kawm Master. Nws cov kev tshawb fawb tau luam tawm nyob rau hauv cov ntaub ntawv muaj txiaj ntsig zoo rau cov neeg txheeb xyuas nrog rau PLOS Tsis pom zoo Cov Kab Mob Kub Kub thiab Cov Txheej Txheem Txheej Txheem. Thaum nws tsis ua hauj lwm thiab sau ntawv, Hugo binges rau tons ntawm anime thiab comics, sau thiab sau suab paj nruag ntawm lub bass guitar, shreds lem ntawm lub MTB, plays video games (nws nyiam lo lus "kev ua si"), los yog tinkers nrog txhua yam. . tshuab.
Francisco de Souza, Hugo. (Lub Xya Hli 9, 2023). Ib qho kev sib xyaw tshwj xeeb ntawm cov nroj tsuag muab cov txiaj ntsig zoo tiv thaiv pob txuv. Xov xwm – Kho mob. Tau txais los ntawm https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx nyob rau lub Cuaj Hlis 11, 2023.
Francisco de Souza, Hugo. "Kev sib xyaw tshwj xeeb ntawm cov nroj tsuag rho tawm nrog cov khoom muaj zog tiv thaiv pob txuv." Xov xwm – Kho mob. Cuaj hlis 11, 2023.
Francisco de Souza, Hugo. "Kev sib xyaw tshwj xeeb ntawm cov nroj tsuag rho tawm nrog cov khoom muaj zog tiv thaiv pob txuv." Xov xwm – Kho mob. https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx. (Tau txais lub Cuaj Hlis 11, 2023).
Francisco de Souza, Hugo. 2023. Ib qho tshwj xeeb sib xyaw ntawm cov nroj tsuag rho tawm nrog cov khoom muaj zog tiv thaiv pob txuv. Xov Xwm Kev Kho Mob, nkag mus rau lub Cuaj Hlis 11, 2023, https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx.
Cov duab uas siv hauv "cov ntsiab lus" no tsis muaj feem xyuam rau txoj kev tshawb fawb no thiab ua rau muaj kev nkag siab tag nrho hauv kev qhia tias txoj kev tshawb fawb koom nrog kev sim rau tib neeg. Nws yuav tsum raug tshem tawm tam sim ntawd.
Hauv kev xam phaj ua haujlwm ntawm SLAS EU 2023 lub rooj sib tham hauv Brussels, Belgium, peb tau tham nrog Silvio Di Castro txog nws txoj kev tshawb fawb thiab lub luag haujlwm ntawm kev tswj hwm kev lag luam hauv kev tshawb fawb tshuaj.
Hauv cov podcast tshiab no, Bruker's Keith Stumpo tham txog ntau txoj hauv kev ntawm cov khoom ntuj tsim nrog Enveda's Pelle Simpson.
Hauv kev xam phaj no, NewsMedical tham nrog Quantum-Si CEO Jeff Hawkins txog cov kev cov nyom ntawm cov txheej txheem ib txwm ua rau proteomics thiab yuav ua li cas cov protein tiam tom ntej tuaj yeem ua rau muaj kev ywj pheej ntawm cov protein.
Xov Xwm-Medical.Net muab cov ntaub ntawv kho mob raws li cov lus qhia thiab cov xwm txheej no. Thov nco ntsoov tias cov ntaub ntawv kho mob ntawm lub vev xaib no yog tsim los txhawb, thiab tsis hloov, kev sib raug zoo ntawm tus neeg mob-tus kws kho mob / tus kws kho mob thiab cov lus qhia kho mob uas lawv tuaj yeem muab tau.