Kev taw qhia txog Citrus Aurantium

Citrus Aurantium, ib tsob nroj teej tug mus rau tsev neeg rutaceae, yog dav faib nyob rau hauv Tuam Tshoj. Citrus aurantium yog ib txwm suav lub npe rau txiv qaub. Hauv cov tshuaj suav tshuaj, citrus aurantium yog tshuaj ntsuab pej xeem uas yog siv los ua kom qab los noj mov thiab tswj qi (zog). Nyob rau hauv ltalis, citrus aurantium kuj yog ib txwm siv tshuaj rau pej xeem txij li thaum xyoo pua 16th, siv los kho kub taub hau xws li malaria thiab ua tshuaj tua kab mob. Cov kev tshawb fawb tsis ntev los no tau pom tias citrus aurantium tuaj yeem hloov ephedra hauv kev kho mob rog yam tsis muaj kev phiv los ntawm cov hlab plawv.

Cov txiaj ntsig zoo ntawm citrus aurantium yog hesperidin, neohesperidin, nobiletin, auranetin, aurantiamarin, nuringin, synephrine, limonin.

Cov khoom xyaw nquag

Hesperidin, neohesperidin, nobiletin, D-limonene, auranetin, aurantiamarin, citrin, synephrine, limonin

Lub cev muaj zog

Crystallization, melting point 184-1850C, carbonate crystallization 151-152, yooj yim soluble hauv dej. Bitartrate, melting point 188-189, soluble hauv dej, nyuaj rau yaj hauv ethanol, yuav luag insoluble hauv chloroform, ether. Hydrochloride, tsis muaj xim siv lead ua (ethanol-ethyl ether), melting point 166-167. Lub racemization yog ib qho yooj yim tshwm sim nyob rau hauv lub chromatography sib cais ntawm muaj zog acid thiab base ion pauv resins.

Pharmacological nyhuv
1. Cov nyhuv ntawm lub tsev menyuam: Fructus Aurantii thiab Fructus Aurantii Fructus Decoction los ntawm peb qhov chaw tsim khoom sib txawv (Sichuan, Jiangxi, thiab Hunan) tau pom tias muaj kev cuam tshuam rau lub tsev menyuam hauv vitro ntawm nas (piv txwv thiab tsis cev xeeb tub); Lub tsev menyuam luav tau zoo siab ob qho tib si hauv vivo thiab hauv vitro ( cev xeeb tub thiab tsis xeeb tub). Luav uterine fistula kuj tau ua pov thawj los ua kom lub tsev menyuam muaj zog, nce nro, thiab txawm tias tetanic contraction. Fructus Aurantii tincture thiab Fructus Aurantii kua extract kuj tuaj yeem ua rau luav uterus (hauv vivo thiab hauv vitro). Nas uterus (hauv vitro) tau inhibited. Ib qho tshuaj alkaloid cais los ntawm Fructus Aurantii thiab Lycium txiv kab ntxwv kuj muaj qee yam kev cog lus ntawm luav uterus hauv vitro, tshwj xeeb tshaj yog nyob rau hauv cov leeg nqaij uterine los ntawm pituitrin. Ib feem ntawm alkaloid tshem tawm tau muaj kev so ntawm lub tsev menyuam luav hauv vitro, thiab cov nyhuv so ntawm lub tsev menyuam tau pom tseeb dua tom qab hypophysial excitation. Cirantin, cais los ntawm Fructus Aurantii Fructus Peel, inhibits hyaluronate kev ua nyob ib ncig ntawm zes qe menyuam, uas tej zaum yuav muaj feem xyuam rau nws cov nyhuv contraceptive (tiv thaiv fertilization).

2. Cov nyhuv ntawm txoj hnyuv: Fructus Aurantii thiab Fructus Aurantii los ntawm peb qhov chaw sib txawv inhibited txoj hnyuv hauv nas thiab luav; Feem ntau ntawm cov hnyuv hauv cov luav tau inhibited, tab sis ob peb tsis muaj kev hloov pauv. Fructus Aurantii thiab nws cov kua extract inhibited lub plab hnyuv ntawm nas (hauv vitro) thiab luav (hauv vitro). Cov concentration siab (1: 1000) inhibited txoj hnyuv me ntawm cov luav thiab cov npua guinea thiab inhibited cov teebmeem ntawm acetylcholine thiab histamine. Tsawg concentration (1: 10 000), tom qab lub sij hawm luv luv ntawm inhibition, tuaj yeem ua rau muaj kev txaus siab, amplitude nce, thiab zaus nrawm. Nyob rau hauv cov dev anesthetized, lub xub ntiag ntawm txoj hnyuv yog inhibited obviously los ntawm decoctions. Tab sis rau cov dev uas muaj gastroenterostomy, nws muaj qee yam excitatory nyhuv, uas tuaj yeem ua rau lub plab zom mov txav thiab ua kom lub cev muaj zog.

3. cuam tshuam rau lub plawv thiab cov hlab ntsha: me me ntawm excitability thiab loj npaum li cas ntawm inhibition ntawm lub plawv ntawm toad hauv vitro. Fructus Aurantii thiab Fructus Aurantii Aurantii aqueous decoction, Fructus Aurantii tincture, thiab kua extract yog tib yam. Fructus Aurantii decoction los yog cawv extract txhaj intravenously tuaj yeem ua rau lub zog tseem ceeb. Fructus Aurantii thiab Fructus Aurantii Fructus los ntawm peb qhov chaw sib txawv tau ua pov thawj tias muaj mob vasoconstriction me me los ntawm tag nrho lub cev vascular perfusion ntawm toads. Hauv cov dev uas siv tshuaj loog, muaj qhov tseem ceeb thiab nrawm nrawm. Tsis muaj kev nyuaj siab ua pa lossis hypotension tshwm sim los ntawm epinephrine, thiab tsis muaj qhov pom tseeb ntawm lub plawv dhia.

Lub siab-boosting mechanism muaj feem xyuam rau cov hauv qab no:

3.1. Excitation ntawm α receptors, ua rau vasoconstriction nyob rau hauv qee lub cev (phenylzoline tuaj yeem thim rov qab siab rau hauv cov tshuaj tiv thaiv ntshav siab).

3.2. Txhim kho myocardial contraction thiab nce lub plawv tso zis (kev cais guinea npua lub plawv perfusion thiab cardiopulmonary npaj). Tom qab reserpine, lub zog-boosting nyhuv ntawm Fructus aurantii aurantii yog qhov tseem ceeb. Nws ua rau cov hlab ntsha loj zuj zus ntxiv (289.4% nce coronary artery flow los ntawm npuas flowmeter) thiab nce lub hlwb thiab lub raum cov ntshav ntws los ntawm 86.4% thiab 64.5% ntawm qhov nruab nrab, uas txawv ntawm norepinephrine. Muaj qhov txo qis hauv cov ntshav femoral thiab me ntsis tab sis tsis tseem ceeb nce hauv myocardial oxygen noj, uas tsis sib haum nrog kev nce ntxiv hauv coronary txaus. Hauv kev kuaj ECG hauv cov dev thiab guinea npua, arrhythmia (ventricular tachycardia los yog atrioventricular block) tshwm sim los ntawm ntau npaum li cas ntawm aurantii aurantii tsis loj. Raws li cov yam ntxwv saum toj no, nws tau pom zoo los kho cardiogenic poob siab. Alkaloids cais los ntawm Fructus Aurantii thiab Lycium txiv kab ntxwv kuj tuaj yeem txhim kho qhov nro ntawm cov leeg nqaij leeg, tshwj xeeb tshaj yog thaum kho nrog pituitrin.

4. Antithrombotic: Hauv vitro kuaj ntawm 0.1g / ml Fructus Aurantii aqua decoction pom muaj cov nyhuv antithrombotic.

5. Cov tshuaj tiv thaiv kev ua xua: 100mg / kg static pulse txhaj ntawm Fructus Aurantii Aurantii dej extract tuaj yeem cuam tshuam cov tawv nqaij tsis haum (PCA) hauv nas, thiab 50μg / ml tuaj yeem inhibit histamine tso tawm ntawm nas plab plab mast hlwb.

6. Lwm yam teebmeem: Citrus cog mycin tuaj yeem txo cov ntsiab lus ntawm cholesatin hauv cov ntshav thiab daim siab ntawm cov nas noj nrog cov zaub mov muaj roj cholesterol. Cov cawv extract ntawm Fructus Aurantii muaj cov nyhuv inhibitory ntawm mycobacterium tuberculosis H37Rv hauv vitro, thiab nws cov inhibitory concentration yog 1: 1000. Nws aqueous decoction tsis cuam tshuam rau guinea npua bronchus. Nws tau raug tshaj tawm tias citrus txiv hmab txiv ntoo kua txiv tsub kom fermentation tus nqi ntawm poov xab thiab tsis txo nws cov kev ua tom qab boiling, yog li nws tsis yog ib tug enzymatic tivthaiv. Kev kho mob tseem ceeb ntawm cov kua txiv kab ntxwv yog tias nws muaj vitamin C thiab muaj ntau cov vitamins A thiab B. Cov tev tsis muaj vitamin C tab sis muaj vitamin A. Nws qab qab thiab tuaj yeem ua kom lub plab. Cov menyuam yaus xws li noj ntau cov tev tuaj yeem ua rau muaj tshuaj lom (mob plab, cramps).

Siv: http://www.a-hospital.com

RauCitrus Aurantium Extract, thov hu rau peb. Peb tos koj ntawm no txhua lub sijhawm !!!