Kev Taw Qhia Txog Citrus Aurantium

Citrus Aurantium, ib tsob nroj uas yog tsev neeg rutaceae, muaj ntau nyob hauv Suav teb. Citrus aurantium yog lub npe Suav ib txwm rau txiv qaub. Hauv cov tshuaj suav ib txwm, citrus aurantium yog cov tshuaj ntsuab ib txwm uas feem ntau yog siv los ua kom muaj kev ntshaw thiab tswj qi (zog). Hauv Ltalis, citrus aurantium kuj yog ib qho tshuaj kho mob ib txwm txij li xyoo pua 16th, siv los kho mob kub taub hau xws li malaria thiab ua tus neeg sawv cev tua kab mob. Cov kev tshawb fawb tsis ntev los no tau qhia tias citrus aurantium tuaj yeem hloov ephedra hauv kev kho mob rog dhau yam tsis muaj kev phiv tsis zoo rau lub plawv.

Cov khoom xyaw zoo ntawm citrus aurantium yog hesperidin, neohesperidin, nobiletin, auranetin, aurantiamarin, nuringin, synephrine, limonin.

Cov khoom xyaw nquag

hesperidin, neohesperidin, nobiletin, D-limonene, auranetin, aurantiamarin, citrin, synephrine, limonin

Khoom siv lub cev

Crystallization, melting point 184-1850C, carbonate crystallization 151-152, yooj yim soluble hauv dej. Bitartrate, melting point 188-189, soluble hauv dej, nyuaj rau yaj hauv ethanol, yuav luag tsis yaj hauv chloroform, ether. Hydrochloride, siv lead ua tsis muaj xim (ethanol-ethyl ether), melting point 166-167. Qhov racemization yooj yim tshwm sim hauv chromatography sib cais ntawm cov kua qaub muaj zog thiab cov tshuaj ion pauv.

Cov nyhuv tshuaj
1. Cov nyhuv rau lub tsev menyuam: Fructus Aurantii thiab Fructus Aurantii Fructus Decoction los ntawm peb thaj chaw sib txawv (Sichuan, Jiangxi, thiab Hunan) tau qhia txog kev cuam tshuam rau lub tsev menyuam hauv vitro ntawm nas (cev xeeb tub thiab tsis cev xeeb tub); Lub tsev menyuam luav tau zoo siab ob qho tib si hauv vivo thiab hauv vitro (cev xeeb tub thiab tsis cev xeeb tub). Lub tsev menyuam luav fistula kuj tau ua pov thawj tias ua rau lub tsev menyuam contractions muaj zog, nce kev nruj, thiab txawm tias tetanic contraction. Fructus Aurantii tincture thiab Fructus Aurantii kua extract kuj tuaj yeem ua rau lub tsev menyuam luav zoo siab (hauv vivo thiab hauv vitro). Lub tsev menyuam nas (hauv vitro) tau raug txwv. Ib qho alkaloid tshuaj cais los ntawm Fructus Aurantii thiab Lycium txiv kab ntxwv kuj muaj qee qhov kev cuam tshuam rau lub tsev menyuam luav hauv vitro, tshwj xeeb tshaj yog rau cov leeg nqaij hauv tsev menyuam uas zoo siab los ntawm pituitrin. Ib feem ntawm cov alkaloid tshem tawm muaj qhov cuam tshuam rau lub tsev menyuam luav hauv vitro, thiab qhov cuam tshuam ntawm lub tsev menyuam tau pom tseeb dua tom qab hypophysial excitation. Cirantin, cais tawm ntawm Fructus Aurantii Fructus Peel, tiv thaiv hyaluronate kev ua ub no nyob ib puag ncig lub zes qe menyuam, uas tej zaum yuav muaj feem cuam tshuam nrog nws cov nyhuv tiv thaiv kev xeeb tub (tiv thaiv kev xeeb tub).

2. Cov nyhuv rau txoj hnyuv: Fructus Aurantii thiab Fructus Aurantii los ntawm peb qhov chaw nyob sib txawv inhibited txoj hnyuv hauv nas thiab luav; Feem ntau ntawm cov hlab ntsha hauv luav tau inhibited, tab sis ob peb tsis muaj kev hloov pauv. Fructus Aurantii thiab nws cov kua dej extract inhibited cov hlab ntsha hauv nas (hauv vitro) thiab luav (hauv vitro). Kev concentration siab (1: 1000) inhibited txoj hnyuv me me ntawm cov luav cais thiab guinea npua thiab inhibited cov teebmeem ntawm acetylcholine thiab histamine. Kev concentration qis (1:10 000), tom qab lub sijhawm luv luv ntawm kev inhibition, tuaj yeem qhia txog kev cuam tshuam excitatory, amplitude nce, thiab zaus accelerated. Hauv cov dev anesthetized, qhov muaj nyob ntawm txoj hnyuv tau inhibited pom tseeb los ntawm decoctions. Tab sis rau cov dev nrog gastroenterostomy, nws muaj qee yam excitatory nyhuv, uas tuaj yeem ua rau lub plab zom mov txav thiab contraction rhythm muaj zog.

3. Cov teebmeem rau lub plawv thiab cov hlab ntsha: me me ntawm kev zoo siab thiab ntau ntawm kev txwv tsis pub rau lub plawv ntawm qav hauv vitro. Fructus Aurantii thiab Fructus Aurantii Aurantii aqueous decoction, Fructus Aurantii tincture, thiab kua extract yog tib yam. Fructus Aurantii decoction lossis cawv extract txhaj rau hauv cov hlab ntsha tuaj yeem ua rau muaj kev nce siab tseem ceeb. Fructus Aurantii thiab Fructus Aurantii Fructus los ntawm peb qhov chaw nyob sib txawv tau ua pov thawj tias muaj cov teebmeem vasoconstriction me me los ntawm kev sib xyaw ua ke ntawm cov qav thoob plaws lub cev. Hauv cov dev anesthetized, muaj qhov cuam tshuam loj thiab sai hypertension. Tsis muaj kev nyuaj siab ua pa lossis hypotension los ntawm epinephrine, thiab tsis muaj kev nce siab pom tseeb hauv lub plawv dhia.

Lub tshuab ua kom lub zog siab muaj feem cuam tshuam nrog cov hauv qab no:

3.1. Kev ua kom cov α receptors ua haujlwm zoo, ua rau cov hlab ntsha me me hauv qee lub cev (phenylzoline tuaj yeem hloov pauv qhov siab uas nce mus rau hauv cov tshuaj tiv thaiv ntshav siab).

3.2. Ua kom lub plawv dhia ceev dua thiab ua rau lub plawv tso zis ntau dua (kev sib xyaw ua ke ntawm cov nas tsuag guinea thiab kev npaj cardiopulmonary). Tom qab reserpine, cov nyhuv ua rau lub siab ntawm Fructus aurantii aurantii tseem ceeb dua. Nws ua rau cov hlab ntsha hauv lub plawv dhia ntau dua (289.4% ua rau cov hlab ntsha hauv lub plawv dhia ntau dua los ntawm lub ntsuas dej npuas) thiab ua rau cov ntshav hauv lub hlwb thiab lub raum nce ntxiv 86.4% thiab 64.5% qhov nruab nrab, uas txawv ntawm norepinephrine. Muaj kev txo qis ntawm cov ntshav ntws hauv lub femoral thiab kev siv oxygen hauv lub plawv me ntsis tab sis tsis tseem ceeb, uas tsis sib xws nrog kev nce ntxiv ntawm cov ntshav ntws hauv lub plawv dhia. Hauv kev kuaj ECG hauv dev thiab nas tsuag guinea, arrhythmia (ventricular tachycardia lossis atrioventricular block) uas tshwm sim los ntawm kev siv ntau ntawm aurantii aurantii tsis loj heev. Raws li cov yam ntxwv saum toj no, nws tau raug pom zoo kom kho cov neeg mob cardiogenic shock. Alkaloids cais los ntawm Fructus Aurantii thiab Lycium txiv kab ntxwv kuj tseem tuaj yeem ua rau cov leeg nqaij du ntawm cov hlab ntsha nce ntxiv ib ntus, tshwj xeeb tshaj yog thaum kho nrog pituitrin.

4. Tshuaj tua kab mob: Kev sim tshuaj hauv vitro ntawm 0.1g / ml Fructus Aurantii aqua decoction tau qhia txog cov nyhuv antithrombotic.

5. Kev tiv thaiv kev ua xua: 100mg/kg static pulse txhaj tshuaj ntawm Fructus Aurantii Aurantii dej extract tuaj yeem tiv thaiv kev ua xua rau daim tawv nqaij (PCA) hauv nas, thiab 50μg/ml tuaj yeem tiv thaiv kev tso tawm histamine los ntawm cov hlwb mast hauv plab nas.

6. Lwm yam teebmeem: Cov nroj tsuag citrus mycin tuaj yeem txo cov ntsiab lus ntawm cholestatin hauv cov ntshav thiab daim siab ntawm cov nas uas pub nrog cov zaub mov uas muaj roj cholesterol. Cov cawv extract ntawm Fructus Aurantii muaj cov nyhuv inhibitory rau mycobacterium tuberculosis H37Rv hauv vitro, thiab nws cov concentration inhibitory yog 1: 1000. Nws cov dej decoction tsis muaj cov nyhuv rau guinea npua bronchus. Nws tau raug tshaj tawm tias cov kua txiv hmab txiv ntoo citrus ua rau cov poov xab fermentation nce thiab tsis txo nws cov haujlwm tom qab boiling, yog li nws tsis yog ib qho enzymatic tivthaiv. Kev siv tshuaj kho mob tseem ceeb ntawm cov kua txiv kab ntxwv yog tias nws nplua nuj nyob rau hauv vitamin C thiab muaj ntau ntawm cov vitamins A thiab B. Lub tev tsis muaj vitamin C tab sis nplua nuj nyob rau hauv vitamin A. Nws saj iab thiab tuaj yeem ua rau lub plab muaj zog. Cov menyuam yaus xws li noj ntau ntawm tev tuaj yeem ua rau lom (mob plab, mob plab).

Siv rau: http://www.a-hospital.com

RauCitrus Aurantium Extract, thov hu rau peb. Peb tos koj ntawm no txhua lub sijhawm!!!