Mob ntsws cancer yog hom mob cancer thib ob hauv ntiaj teb. Xyoo 2020, ntau dua 2.2 lab tus tib neeg thoob ntiaj teb yuav raug kuaj mob ntsws cancer thawj zaug. Hauv tib lub xyoo, kwv yees li 1.8 lab tus tib neeg thoob ntiaj teb tau tuag los ntawm mob ntsws cancer.
Txawm hais tias tam sim no tsis muaj kev kho mob ntsws cancer, cov kws tshawb fawb tab tom ua haujlwm rau kev kho mob. Qee cov kws tshawb fawb no ua haujlwm ntawm University of Technology Sydney (UTS), qhov twg txoj kev tshawb fawb tshiab tau pom tias cov nroj tsuag ntuj hu ua berberine tuaj yeem nres qhov kev loj hlob ntawm cov qog nqaij hlav hauv lub ntsws hauv chav kuaj.
Berberine yog ib qho chaw cog qoob loo uas tau siv hauv cov tshuaj suav tshuaj rau ntau txhiab xyoo. Nws muaj nyob rau hauv ntau yam nroj tsuag, xws li barberry, goldenseal, Oregon txiv hmab txiv ntoo, thiab tsob ntoo turmeric.

(Peb cov khoom yogBerberine Extract, zoo siab txais tos rau kev nug.)

Ntau xyoo kev tshawb fawb tau pom tias berberine muaj txiaj ntsig zoo hauv kev pab cov neeg mob ntshav qab zib hom 2 tswj lawv cov ntshav qab zib thiab tuaj yeem pab kho cov mob metabolic.
Cov kws tshawb fawb kuj tau pom tias berberine tuaj yeem siv los kho ntau yam qog noj ntshav, suav nrog zes qe menyuam, plab, thiab mob qog noj ntshav mis.
Raws li Dr. Kamal Dua, Senior Lecturer thiab Senior Research Fellow hauv Pharmacy ntawm Australian Research Center for Complementary and Integrative Medicine (ARCCIM), University of Technology Sydney (UTS) Lub Tsev Kawm Ntawv Tshuaj thiab tus thawj coj ntawm txoj kev tshawb no, Berberine inhibits ob lub ntsiab lus. Cov txheej txheem hauv kev loj hlob qog nqaij hlav - Kev loj hlob thiab kev tsiv teb tsaws ntawm tes.
"Mechanically, qhov no tuaj yeem ua tiav los ntawm inhibiting cov noob tseem ceeb xws li P53, PTEN thiab KRT18 thiab cov proteins xws li AXL, CA9, ENO2, HER1, HER2, HER3, PRGN, PDGF-AA, DKK1, CTSB, CTSD, BCLX, CSF1. thiab CAPG cuam tshuam nrog kev loj hlob thiab kev tsiv teb tsaws ntawm cov qog nqaij hlav cancer, "nws piav qhia.
Hauv txoj kev tshawb fawb tam sim no, pab pawg tshawb fawb suav nrog Dr. Dua, Dr. Keshav Raj Paudel, xibfwb Philip M. Hansbrough thiab Dr. Bikash Manandhar ntawm UTS, nrog rau cov neeg ua haujlwm los ntawm Malaysian International Medical University thiab Al Qasim University hauv Saudi Arabia, kawm yuav ua li cas berberine tuaj yeem siv los kho mob qog noj ntshav.
"Kev siv tshuaj kho mob ntawm berberine raug txwv vim nws tsis zoo solubility thiab bioavailability," Dr. Dua rau MNT piav qhia. "Lub hom phiaj tseem ceeb ntawm txoj kev tshawb no yog txhawm rau txhim kho physicochemical tsis ntawm berberine los ntawm kev hloov berberine rau hauv cov kua siv lead ua nanoparticles thiab tshawb nrhiav nws cov peev xwm tiv thaiv kab mob hauv vitro ntawm alveolar epithelial basal hlwb ntawm tib neeg adenocarcinoma A549."
Pab neeg tshawb fawb tau tsim ib qho kev xa tshuaj zoo tshaj plaws uas encapsulates berberine hauv me me soluble thiab biodegradable spheres. Cov kua siv lead ua kua nanoparticles no tau siv los kho tib neeg lub ntsws cancer hlwb hauv vitro hauv chav kuaj.
Thaum kawg ntawm txoj kev tshawb no, pab pawg pom tau hais tias berberine pab thaiv kev tsim cov pa oxygen reactive, cov tshuaj inflammatory uas tsim los ntawm qee lub hlwb los teb rau cov kab mob ntxeem tau thiab lwm yam kev ntxhov siab uas tuaj yeem ua rau lub hlwb puas.
Tsis tas li ntawd, berberine pab tswj cov noob uas cuam tshuam nrog oxidative kev nyuaj siab thiab o, thiab pab txo qis cell aging.
"Peb tau ua pov thawj tias, siv txoj hauv kev nanotechnological, cov khoom ntawm cov khoom sib xyaw tuaj yeem txhim kho kom daws tau ntau yam teeb meem ntsig txog solubility, cellular uptake, thiab kho tau zoo," piav qhia Dr. Dua. Anticancer Potential Peb berberine kua siv lead ua nanoparticles qhia tib yam kev ua ntawm tsib zaug koob tshuaj piv rau cov ntaub ntawv luam tawm, qhia meej meej cov txiaj ntsig ntawm nanodrugs. "
Txhawm rau sim ntxiv cov txiaj ntsig no, Dr. Dua tau hais tias nws npaj yuav siv lub vev xaib tshawb fawb tshiab los ua cov kev tshawb fawb tob tob uas siv cov qauv tsiaj preclinical ntawm mob ntsws cancer.
"Txoj kev tshawb fawb tshuaj pharmacokinetic thiab anticancer ntxiv ntawm berberine nanodrugs hauv cov qauv tsiaj hauv vivo tuaj yeem nthuav tawm lawv cov txiaj ntsig zoo hauv kev kho mob qog noj ntshav thiab hloov lawv mus rau hauv cov ntaub ntawv kho mob," nws piav qhia.
"Thaum peb tau lees paub qhov muaj peev xwm tiv thaiv kabmob kheesxaws ntawm berberine nanodrugs hauv cov qauv tsiaj preclinical, cov kauj ruam tom ntej yuav hloov mus rau kev sim tshuaj, uas peb twb tau tham nrog ntau lub tuam txhab Sydney," said Dr. Dua.
Tsis tas li ntawd, Dr. Dua tau hais tias lub peev xwm ntawm berberine los tiv thaiv kev mob ntsws cancer yuav tsum tau lees paub: "Txawm hais tias peb tseem tsis tau tshawb xyuas qhov no, peb npaj yuav kawm nws hauv kev tshawb fawb yav tom ntej, thiab peb kuj ntseeg tias berberine nanoforms yuav qhia. kev cog lus ua haujlwm. ".
Dr. Osita Onuga, tus kws phais mob thoracic thiab tus pab xibfwb ntawm kev phais thoracic ntawm St. John Cancer Institute ntawm Providence St. John Medical Center hauv Santa Monica, California, tau hais rau MNT tias thaum cov kws tshawb fawb nrhiav tau txoj hauv kev tshiab los kho thiab tiv thaiv kabmob kheesxaws, yeej ib txwm muaj. kev cia siab:
"Berberine yog ib feem ntawm cov tshuaj Eastern, yog li peb ib txwm tsis siv nws hauv Western tshuaj. Kuv xav tias nws yog qhov nthuav vim peb tab tom saib qhov peb paub tias muaj qee qhov txiaj ntsig rau cov khoom siv tshuaj sab hnub tuaj, thiab muab tso rau hauv kev tshawb fawb los pab txhais cov tshuaj Western. ".
"Nws ib txwm muaj kev cia siab, tab sis nws nyob hauv chav kuaj, thiab ntau yam peb pom hauv chav kuaj tsis tas yuav ua rau cov neeg mob raug kho," Onuga txuas ntxiv. "Kuv xav tias yam tom ntej yuav ua yog ua qee qhov kev sim tshuaj rau cov neeg mob thiab txheeb xyuas qhov ntau npaum li cas."
Qee tus neeg muaj cov tsos mob me me ntawm lub ntsws cancer thaum ntxov ntawm tus kab mob. Nyeem ntxiv kom paub ntau ntxiv, suav nrog thaum mus ntsib kws kho mob.
Mob ntsws cancer tshwm sim ntawm tus nqi sib txawv ntawm cov poj niam thiab cov txiv neej, tab sis cov tsos mob thiab kev pheej hmoo yog tib yam. Ntawm no peb piav qhia txog cov caj ces thiab hormonal…
Peb yog cov kws tshaj lij cog extract hmoov chaw tsim tshuaj paus, txais tos xa koj cov lus nug txog peb cov khoom thiab peb muaj lub luag haujlwm ua haujlwm los daws koj cov teeb meem txog kev muag khoom ua ntej thiab tom qab muag. Tiv tauj peb txhua lub sijhawm !!!