Ntawm cov ntaub ntawv tshiab tshaj plaws ntawm qhov muaj zog antioxidant no yog kev tshuaj xyuas luam tawm hauv Phytotherapy Research thaum Lub Peb Hlis 2019, uas tau tshuaj xyuas 9 yam khoom hais txog qhov cuam tshuam ntawm quercetin ntawm metabolic syndrome Randomized tswj kev sim.

Cov kab mob metabolic hais txog cov teeb meem kev noj qab haus huv uas ua rau muaj kev pheej hmoo ntawm hom 2 mob ntshav qab zib mellitus, kab mob plawv, thiab mob stroke, suav nrog ntshav siab, ntshav qab zib siab, qib triglyceride siab, thiab lub duav rog.

Txawm hais tias muaj kev tshawb fawb pom tau tias quercetin tsis muaj kev cuam tshuam rau kev yoo ntshav qabzib, insulin tsis kam lossis qib hemoglobin A1c, ntxiv kev soj ntsuam pab pawg pom tau tias quercetin tau ntxiv rau hauv cov kev tshawb fawb uas tau noj tsawg kawg 500 mg ib hnub rau tsawg kawg yim lub lis piam. " Txo cov ntshav qab zib kom sai sai.

Quercetin pab tswj cov noob qhia

Raws li kev tshawb fawb luam tawm xyoo 2016, quercetin tseem tuaj yeem ua rau lub mitochondrial channel ntawm apoptosis (programmed cell tuag ntawm cov hlwb puas) los ntawm kev cuam tshuam nrog DNA, yog li ua rau qog regression.

Cov kev tshawb fawb tau pom tias quercetin tuaj yeem ua rau cytotoxicity ntawm leukemia hlwb, thiab cov nyhuv cuam tshuam rau cov koob tshuaj. Cov teebmeem cytotoxic tsawg kuj tau pom hauv cov qog nqaij hlav cancer mis. Feem ntau, quercetin tuaj yeem txuas ntxiv lub neej ntawm cov nas mob qog noj ntshav los ntawm 5 zaug piv nrog cov pab pawg tswj tsis tau kho.

Cov kws sau ntawv ntaus nqi rau cov teebmeem no rau kev sib cuam tshuam ncaj qha ntawm quercetin thiab DNA thiab nws txoj kev ua haujlwm ntawm mitochondrial txoj hauv kev ntawm apoptosis, thiab qhia tias muaj peev xwm siv quercetin ua ib qho tshuaj ntxiv rau kev kho mob qog noj ntshav yog tsim nyog rau kev tshawb nrhiav ntxiv.

Ib txoj kev tshawb fawb tsis ntev los no tau luam tawm nyob rau hauv phau ntawv journal Molecules tseem hais txog cov teebmeem epigenetic ntawm quercetin thiab nws lub peev xwm los:

Kev sib tham nrog xov tooj ntawm tes taw qhia channel
Tswj kev qhia gene
Muaj feem cuam tshuam rau kev ua haujlwm ntawm kev hloov pauv
Tswj microribonucleic acid (microRNA)

Microribonucleic acid yog ib zaug suav tias yog "quav" DNA. Cov kev tshawb fawb tau pom tias DNA "khib nyiab" tsis muaj txiaj ntsig. Nws yog ib tug me me molecule ntawm ribonucleic acid, uas plays lub luag hauj lwm tseem ceeb hauv kev tswj cov noob uas ua rau tib neeg cov proteins.

Microribonucleic acid tuaj yeem siv los ua "hloov" ntawm cov noob no. Raws li cov tswv yim ntawm microribonucleic acid, cov noob tuaj yeem nkag mus rau ib qho ntawm ntau tshaj 200 cov khoom lag luam protein. Quercetin lub peev xwm los hloov kho microRNAs kuj tseem tuaj yeem piav qhia nws cov teebmeem cytotoxic thiab vim li cas nws zoo li ua rau mob qog noj ntshav (tsawg kawg rau cov nas).

Quercetin yog ib qho muaj zog tiv thaiv kab mob

Raws li tau hais los saum no, kev tshawb fawb tau ua nyob ib puag ncig quercetin tsom rau nws cov peev xwm tiv thaiv kab mob, uas yog vim muaj peb lub tswv yim ntawm kev ua:

Inhibit lub peev xwm ntawm cov kab mob kis mus rau lub hlwb
Inhibit the replication ntawm cov kab mob
Txo qhov tsis kam ntawm cov kab mob kis mus rau kev kho tshuaj tiv thaiv kab mob

Piv txwv li, ib txoj kev tshawb nrhiav nyiaj txiag los ntawm US Department of Defense luam tawm xyoo 2007 pom tias tom qab muaj kev ntxhov siab rau lub cev, quercetin tuaj yeem txo koj txoj kev pheej hmoo kis tus kab mob thiab txhim kho koj lub hlwb kev ua haujlwm, txwv tsis pub nws yuav ua rau koj lub cev tsis muaj zog, ua rau koj raug mob ntau dua. rau kab mob.

Hauv txoj kev tshawb no, cov neeg caij tsheb kauj vab tau txais 1000 mg ntawm quercetin ib hnub, ua ke nrog cov vitamin C (nce qib plasma quercetin) thiab niacin (txhawb kev nqus) rau tsib lub lis piam sib law liag. Cov txiaj ntsig tau pom tias piv nrog tsis kho Rau ib tus neeg caij tsheb kauj vab uas tau kho, cov neeg uas noj quercetin muaj feem tsawg dua ntawm kev kis tus kab mob kis tom qab caij tsheb kauj vab peb teev ib hnub rau peb hnub sib law liag. 45% ntawm cov neeg hauv pawg placebo tau mob, thaum tsuas yog 5% ntawm cov neeg hauv pab pawg kho mob tau mob.

Lub Chaw Haujlwm Saib Xyuas Kev Ruaj Ntseg Hauv Tebchaws Meskas (DARPA) tau pab nyiaj rau lwm txoj kev tshawb fawb, uas tau luam tawm xyoo 2008, thiab tau kawm txog kev siv tus kab mob khaub thuas H1N1 uas muaj kab mob khaub thuas hnyav heev los tawm tsam cov tsiaj kho nrog quercetin. Qhov tshwm sim tseem zoo li qub, qhov mob thiab kev tuag ntawm pab pawg kho mob tau qis dua li ntawm pawg placebo. Lwm cov kev tshawb fawb kuj tau lees paub qhov ua tau zoo ntawm quercetin tiv thaiv ntau yam kab mob, suav nrog:

Ib txoj kev tshawb fawb xyoo 1985 pom tias quercetin tuaj yeem tiv thaiv tus kab mob thiab rov ua dua ntawm tus kab mob herpes simplex virus type 1, poliovirus type 1, parainfluenza virus type 3, thiab respiratory syncytial virus.

Ib txoj kev tshawb fawb tsiaj hauv xyoo 2010 pom tias quercetin tuaj yeem tiv thaiv kab mob khaub thuas A thiab B. Kuj tseem muaj ob qhov kev tshawb pom loj. Ua ntej, cov kab mob no tsis tuaj yeem tiv thaiv quercetin; Qhov thib ob, yog tias lawv tau siv nrog cov tshuaj tiv thaiv kab mob (amantadine lossis oseltamivir), lawv cov teebmeem tau txhim kho zoo heev - thiab kev txhim kho ntawm kev tiv thaiv yog tiv thaiv.

Kev tshawb nrhiav tsiaj hauv xyoo 2004 tau pom zoo ib hom kab mob H3N2, tshawb xyuas cov txiaj ntsig ntawm quercetin ntawm tus mob khaub thuas. Tus sau tau taw qhia:

"Thaum kis tus kab mob khaub thuas, oxidative kev nyuaj siab tshwm sim. Vim hais tias quercetin tuaj yeem kho cov concentration ntawm ntau cov tshuaj antioxidants, qee cov neeg xav tias nws yuav yog ib qho tshuaj zoo uas tuaj yeem tiv thaiv lub ntsws los ntawm kev tso tawm thaum kis kab mob khaub thuas. "

Lwm txoj kev tshawb fawb xyoo 2016 tau pom tias quercetin tuaj yeem tswj hwm cov protein qhia thiab muaj kev tiv thaiv kab mob khaub thuas H1N1. Tshwj xeeb, kev tswj hwm ntawm cov protein ua kom sov, fibronectin 1 thiab inhibitory protein pab txo tus kab mob rov ua dua tshiab.

Ib txoj kev tshawb fawb thib peb luam tawm xyoo 2016 pom tias quercetin tuaj yeem tiv thaiv ntau yam kab mob khaub thuas, suav nrog H1N1, H3N2, thiab H5N1. Tus sau ntawm tsab ntawv tshawb fawb ntseeg hais tias, "Qhov kev tshawb fawb no qhia tau hais tias quercetin nthuav tawm cov haujlwm inhibitory nyob rau theem pib ntawm tus kab mob khaub thuas, uas muab txoj kev npaj kho mob yav tom ntej los ntawm kev txhim kho cov tshuaj zoo, nyab xeeb, thiab pheej yig los kho thiab tiv thaiv [Influenza. Ib tug kab mob] kab mob."

Hauv xyoo 2014, cov kws tshawb fawb tau taw qhia tias quercetin "zoo li cog lus hauv kev kho mob khaub thuas los ntawm rhinoviruses" thiab ntxiv, "Kev tshawb fawb tau lees paub tias quercetin tuaj yeem txo qis kev sib txuas thiab rov ua dua ntawm cov kab mob hauv vitro. Lub cev tuaj yeem txo cov kab mob khaub thuas, mob ntsws thiab ua pa hauv pa. "

Quercetin tseem tuaj yeem txo cov kev puas tsuaj oxidative, yog li txo qhov kev pheej hmoo ntawm kev kis kab mob thib ob, uas yog qhov ua rau mob khaub thuas tuag. Qhov tseem ceeb, quercetin nce mitochondrial biosynthesis nyob rau hauv cov leeg pob txha, qhia tias ib feem ntawm nws cov tshuaj tiv thaiv kab mob yog vim qhov txhim kho mitochondrial antiviral teeb liab.

Kev tshawb fawb tsiaj hauv xyoo 2016 pom tias quercetin tuaj yeem tiv thaiv tus kab mob dengue thiab kab mob siab kab mob hauv cov nas. Lwm cov kev tshawb fawb kuj tau lees paub tias quercetin muaj peev xwm tiv thaiv kab mob siab B thiab C.

Tsis ntev los no, kev tshawb fawb luam tawm nyob rau hauv phau ntawv journal Microbial Pathogenesis nyob rau lub Peb Hlis 2020 pom tias quercetin tuaj yeem muab kev tiv thaiv kev tiv thaiv kab mob Streptococcus pneumoniae ob leeg hauv vitro thiab hauv vivo. Ib qho tshuaj lom (PLY) tso tawm los ntawm pneumococcus los tiv thaiv tus kab mob Streptococcus pneumoniae. Hauv tsab ntawv ceeb toom "Microbial Pathogenesis", tus sau tau taw qhia:

"Cov txiaj ntsig tau pom tias quercetin txo qis kev ua haujlwm hemolytic thiab cytotoxicity tshwm sim los ntawm PLY los ntawm inhibiting qhov tsim ntawm oligomers.
Tsis tas li ntawd, kev kho mob quercetin tuaj yeem txo PLY-mediated cell puas, ua kom cov nas muaj sia nyob nrog cov kab mob ua kom tuag ntawm Streptococcus pneumoniae, txo cov kab mob ntsws, thiab inhibit cytokines (IL-1β thiab TNF) hauv bronchoalveolar lavage kua. -a) tso tawm.
Xav txog qhov tseem ceeb ntawm cov xwm txheej no hauv cov kab mob ntawm cov kab mob Streptococcus pneumoniae, peb cov txiaj ntsig tau qhia tias quercetin tuaj yeem dhau los ua tus neeg siv tshuaj tshiab rau kev kho mob ntawm cov kab mob pneumococcal. "
Quercetin tiv thaiv kev mob thiab txhawb kev tiv thaiv kab mob

Ntxiv nrog rau cov tshuaj tiv thaiv kab mob, quercetin tuaj yeem txhim kho kev tiv thaiv kab mob thiab tiv thaiv kev mob. Ib txoj kev tshawb fawb 2016 luam tawm hauv phau ntawv Journal Nutrients tau taw qhia tias cov txheej txheem ntawm kev ua haujlwm suav nrog (tab sis tsis txwv rau) inhibition ntawm:

• Tumor necrosis factor alpha (TNF-α) induced los ntawm lipopolysaccharide (LPS) hauv macrophages. TNF-α yog ib qho cytokine koom nrog hauv kev mob o. Nws yog secreted los ntawm activated macrophages. Macrophages yog cov tshuaj tiv thaiv kab mob uas tuaj yeem nqos tau cov khoom txawv teb chaws, kab mob thiab lwm yam teeb meem lossis puas tsuaj.
• Lipopolysaccharide-induced TNF-α thiab interleukin (Il)-1α mRNA qib hauv glial hlwb, uas tuaj yeem ua rau "txo qis neuronal cell apoptosis"
• inhibit zus tau tej cov inflammatory-inducing enzymes
• Tiv thaiv calcium los ntawm ntws mus rau hauv hlwb, yog li inhibiting:
◦ Tso cov pro-inflammatory cytokines
◦ Cov kab mob hauv plab hnyuv tso tawm histamine thiab serotonin 

Raws li tsab xov xwm no, quercetin tseem tuaj yeem ua kom cov leeg nqaij ruaj khov, muaj cytoprotective kev ua haujlwm ntawm lub plab zom mov, thiab "muaj kev tswj hwm ncaj qha rau cov yam ntxwv ua haujlwm ntawm lub cev tiv thaiv kab mob", kom nws tuaj yeem "tso cai lossis cuam tshuam ntau yam. Cov kab mob inflammatory thiab kev ua haujlwm, "Inhibit ntau lub hom phiaj molecular hauv micromolar concentration ntau".

Quercetin tej zaum yuav yog ib qho tseem ceeb ntxiv rau ntau tus neeg

Muab rau hauv tus account ntau ntawm cov txiaj ntsig ntawm quercetin, nws yuav yog ib qho txiaj ntsig ntxiv rau ntau tus neeg, txawm tias nws muaj teeb meem loj lossis ntev ntev, nws tuaj yeem muaj qee yam cuam tshuam. Qhov no kuj yog ib qho ntxiv uas kuv xav kom koj khaws cia rau hauv lub txee tshuaj. Nws tuaj yeem ua tau yooj yim thaum koj xav tias koj tab tom yuav "dhau" los ntawm teeb meem kev noj qab haus huv (txawm nws yog khaub thuas lossis mob khaub thuas).

Yog tias koj nquag mob khaub thuas thiab mob khaub thuas, koj tuaj yeem xav txog kev noj quercetin ob peb lub hlis ua ntej lub caij khaub thuas thiab mob khaub thuas los txhawb koj lub cev tiv thaiv kab mob. Nyob rau lub sijhawm ntev, nws zoo li muaj txiaj ntsig zoo rau cov neeg mob metabolic syndrome, tab sis nws yog qhov ruam heev uas tso siab rau qee yam tshuaj thiab tsis daws teeb meem yooj yim xws li kev noj zaub mov thiab kev tawm dag zog tib lub sijhawm.