1. Cov tshuaj tiv thaiv Endothelin

Nws yog rho tawm los ntawm cov tshuaj ntsuab European chamomile, uas tuaj yeem tiv taus endothelin thiab inhibit qhov tsim ntawm melanocytes. Qhov kev faib tawm tsis sib xws ntawm endothelin hauv daim tawv nqaij yog qhov tseem ceeb ua rau muaj kev tsim cov xim. Endothelin antagonists tuaj yeem inhibit endothelin.. tyrosinase thiab txhawb kev sib txawv ntawm melanocytes.

Cov kev tshawb fawb tau pom tias cov tshuaj endothelin antagonists uas tau rho tawm los ntawm cov tsiaj txhu hauv dej muaj cov cytotoxicity tsawg thiab tuaj yeem tiv thaiv qhov sib txawv ntawm endothelin ntawm melanocytes thiab cov haujlwm ntawm tyrosinase. Cov kab mob hyperpigmentation ntawm daim tawv nqaij uas tshwm sim los ntawm kev nce -l yuav muaj kev cia siab rau daim ntawv thov.

2. Resveratrol thiab nws cov khoom siv

Resveratrolfeem ntau muaj nyob rau hauv txiv hmab, Polygonum cuspidatum, Veratrum thiab lwm yam nroj tsuag, thiab inhibits lub luag haujlwm ntawm melanocytes thiab cov haujlwm ntawm tyrosinase nyob rau hauv ib qho concentration-dependent txoj kev, yog li txo melanin synthesis. Jeong et al pom tias nws kuj cuam tshuam nrog tyrosinase-cuam tshuam proteins hauv melanogenesis.

Jia Lili thiab lwm cov kev tshawb fawb tau qhia tias cov tshuaj resveratrol sab nraud tuaj yeem txhim kho cov xim tawv nqaij zoo, muaj qee qhov ua rau dawb, thiab tsis muaj kev phiv tshuaj. Resveratrol muaj qhov tsis zoo ntawm kev tsis ruaj khov thiab kev tsis muaj bioavailability. Cov kev tshawb fawb tau pom tias nws cov derivatives (pentaalkyl ether derivatives thiab tetraester derivatives) muaj bioavailability siab thiab tuaj yeem tiv thaiv kev tsim melanin zoo dua. Nws muaj kev cia siab dav dav hauv kev siv tshuaj pleev ib ce dawb.

3. Cov tshuaj ntsuab Camellia

Camellia yog Camellia genus ntawm tsev neeg Camellia. Nakamura et al. pom tias camellia paj bud extract tuaj yeem tiv thaiv melanin ntau lawm thiab txhawb kev sib txawv ntawm fibroblast. Huang Xiaofeng thiab lwm yam kev tshawb fawb tau xaus lus tias Dianshan tshuaj yej ceg thiab nplooj extract zoo dua li arbutin hauv kev loj hlob ntawm tes thiab kev txwv tsis pub tyrosinase ua haujlwm, thiab muaj cov khoom zoo dua li arbutin. Nws yog ib hom tshuaj dawb tawv nqaij tshiab thiab muaj ntau yam kev siv. prospect.

MelaninSynthaseItus neeg tiv thaiv

1. Arbutin

Nws yog ib qho tseem ceeb tyrosinase inhibitor, uas tuaj yeem tiv thaiv kev ua haujlwm ntawm tyrosinase, thaiv kev tsim cov dopa thiab dopaquinone, yog li ntawd inhibiting qhov tsim ntawm melanin, thiab tseem tuaj yeem txo cov pigmentation los ntawm ultraviolet rays, tab sis nws ruaj khov tsis zoo, nrog rau qee qhov photosensitivity.

Cov kev tshawb fawb pom tau tias arbutin nrog qhov concentration ntawm 3% muaj cov khoom zoo, tsis tshua muaj cytotoxicity, khaus thiab ua xua, thiab qhov siab tshaj plaws ntawm nws qhov concentration tsis pub tshaj 7%. Qhov concentration siab ntawm arbutin yuav ua rau daim tawv nqaij tsis zoo. Nws cov khoom xyaw ntuj, glucopyranoside, muaj cov nyhuv inhibitory rau tib neeg tyrosinase dua li arbutin, thiab hloov arbutin vim nws muaj txiaj ntsig zoo dua thiab ruaj khov.

2. Cov kua txiv qaub ntsuab

Nws cov khoom xyaw nquag yog liquiritin, isoliquiritin thiab licorice flavonoids. Liquiritin ua rau daim tawv nqaij melanin faib sib npaug los ntawm kev faib cov melanin sib sau ua ke, thiab ua tiav cov nyhuv dawb; lub luag haujlwm tseem ceeb ntawm licorice flavonoids yog los tiv thaiv kev ua haujlwm ntawm tyrosinase, DHICA oxidase thiab dopa pigment intermutase.

Cov kev tshawb fawb tau pom tias cov khoom siv kho mob tawv nqaij uas muaj licorice extract thiab papain tuaj yeem pab melasma thiab post-inflammatory hyperpigmentation, nrog rau cov kev tsis zoo tsawg dua, thiab muaj qee yam .. thiab .. khoom. Nws qhov kev sib xyaw hauv cov khoom dawb yog 10% txog 40%, tab sis cov ntsiab lus ntawm cov khoom xyaw nquag hauv licorice tsis siab thiab kev ntxuav yog qhov nyuaj thiab kim.

3. Chuanxiong Extract

Cov kev tshawb fawb tau pom tias Chuanxiong extract tuaj yeem tiv thaiv kev ua haujlwm ntawm tyrosinase, qhia txog kev sib tw inhibitory. Chuanqiong tshuaj pleev tsim los ntawm cov mis sib xyaw ntawm cov emulsifiers sib txawv thiab cov thickeners sib txawv, kev tshawb fawb ntawm nws cov txiaj ntsig dawb thiab kev ua tau zoo qhia tau tias 0.5% ~ 1.0% Chuanqiong tshuaj pleev muaj cov yam ntxwv ntawm kev ruaj khov zoo, kev ua tau zoo thiab cov txiaj ntsig zoo dawb.

4. Rhodiola Rosea Extract

Salidroside thiab flavonoids yog nws cov khoom tseem ceeb, thiab salidroside tuaj yeem ua rau cov lipids thiab cov cell membranes puas tsuaj los ntawm ultraviolet rays. Cov extract tuaj yeem tiv thaiv kev tsim cov melanin thiab kev ua haujlwm ntawm tyrosinase, thiab yog ib qho tshuaj dawb tawv nqaij zoo. Kev tshawb fawb pom tias 1% thiab 5% ntawm Rhodiola rosea extract tsis ua rau muaj kev tsis haum tshuaj hauv tib neeg lub cev, thiab nws yog ib qho khoom xyaw ua kom zoo nkauj nrog kev ruaj khov siab thiab muaj kev cia siab dav dua hauv kev siv tshuaj pleev ib ce.

5. Aloin

Nws yog ib qho glycoprotein uas tsis muaj molecular hnyav uas tau rho tawm los ntawm aloe vera. Nws feem ntau tiv thaiv kev tsim cov dopaquinone los ntawm kev sib tw tiv thaiv qhov chaw oxidation dopa, thiab ua tiav kev tiv thaiv tsis sib tw los ntawm kev sib tw tiv thaiv cov ions tooj liab ntawm qhov chaw hydroxylase. Kev ua haujlwm ntawm tyrosine hydroxylase. Tsis tas li ntawd, aloin kuj tseem tuaj yeem txo qhov tawv nqaij dub los ntawm ultraviolet rays, thiab muaj kev kho zoo rau daim tawv nqaij tom qab raug tshav ntuj. Aloin yog hydrophilic thiab tsis-cytotoxic. Kev sib xyaw aloin nrog arbutin tuaj yeem txhim kho cov nyhuv dawb.

6. Cov Polyphenols cog

Nws feem ntau muaj nyob rau hauv cov tawv ntoo, cov hauv paus hniav, nplooj thiab cov txiv hmab txiv ntoo ntawm cov nroj tsuag, thiab nws cov nyhuv ua kom dawb yog feem ntau cuam tshuam nrog nws cov kev nqus ntawm cov teeb ultraviolet, antioxidant tshem tawm cov free radicals, thiab inhibition ntawm tyrosinase thiab peroxidase kev ua ub no. Ellagic acid yog ib qho polyphenol ntuj rho tawm los ntawm cov tawv ntoo pomegranate, tawv ntoo thiab ntau yam txiv hmab txiv ntoo thiab zaub. Nws tuaj yeem tiv thaiv kev loj hlob ntawm melanocytes, tiv thaiv kev ua haujlwm ntawm melanocyte tyrosinase, txo cov melanin synthesis. Cov teeb ultraviolet muaj cov nyhuv nqus tau zoo, uas tuaj yeem ua lub luag haujlwm hauv kev tiv thaiv hnub lossis scavenging free radicals los ntawm kev nqus cov teeb ultraviolet. Cov nroj tsuag polyphenol yog ib hom khoom xyaw zoo, uas muaj kev cia siab dav rau kev txhim kho thiab siv cov tshuaj pleev ib ce.

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Tus Thawj Coj Txawv Tebchaws: Jason
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