1. Endothelin antagonists

Nws yog muab rho tawm los ntawm European tshuaj ntsuab chamomile, uas yuav tiv thaiv endothelin thiab inhibit zus tau tej cov melanocytes.Qhov tsis sib xws ntawm endothelin nyob rau hauv daim tawv nqaij yog qhov tseem ceeb uas ua rau cov pigmentation.Endothelin antagonists tuaj yeem inhibit endothelin.. tyrosinase thiab txhawb kev sib txawv ntawm melanocytes.

Cov kev tshawb fawb tau pom tias endothelin antagonists muab rho tawm los ntawm cov kab mob hauv dej muaj cytotoxicity tsawg thiab tuaj yeem cuam tshuam qhov sib txawv ntawm endothelin ntawm melanocytes thiab kev ua ntawm tyrosinase.Cov kab mob ntawm daim tawv nqaij hyperpigmentation tshwm sim los ntawm nce -l tuaj yeem muaj daim ntawv thov kev cia siab.

2. Resveratrol thiab nws cov derivatives

ResveratrolFeem ntau muaj nyob rau hauv txiv hmab txiv ntoo, Polygonum cuspidatum, Veratrum thiab lwm yam nroj tsuag, thiab inhibits kev ua ntawm melanocytes thiab cov kev ua ntawm tyrosinase nyob rau hauv ib tug concentration-dependent yam, yog li txo melanin synthesis.Jeong et al pom tias nws tseem cuam tshuam nrog tyrosinase-txog cov proteins hauv melanogenesis.

Jia Lili thiab lwm yam kev tshawb fawb tau pom tias cov tshuaj resveratrol tuaj yeem txhim kho cov xim ntawm daim tawv nqaij, muaj cov nyhuv whitening, thiab tsis muaj kev phiv tshuaj.Resveratrol muaj qhov tsis zoo ntawm kev tsis ruaj khov thiab tsis muaj bioavailability.Cov kev tshawb fawb tau pom tias nws cov derivatives (pentaalkyl ether derivatives thiab tetraester derivatives) muaj bioavailability siab thiab tuaj yeem cuam tshuam zoo rau cov synthesis ntawm melanin.Nws muaj dav daim ntawv thov kev cia siab nyob rau hauv whitening tshuaj pleev ib ce.

3. Camellia Extract

Camellia yog Camellia genus ntawm tsev neeg Camellia.Nakamura et al.pom tias camellia paj paj extract tuaj yeem inhibit melanin ntau lawm thiab txhawb kev sib txawv ntawm fibroblast.Huang Xiaofeng thiab lwm yam kev tshawb fawb tau xaus lus tias Dianshan tshuaj yej ceg thiab nplooj extract yog zoo dua arbutin nyob rau hauv cov nqe lus ntawm cell proliferation thiab inhibition ntawm tyrosinase kev ua si, thiab muaj zoo zog dua arbutin.Nws yog ib hom tshiab ntawm daim tawv nqaij ntxuav hniav dawb thiab muaj ntau yam kev siv.kev cia siab.

MelaninSynthasItus neeg sab nrauv

1. Arbutin

Nws yog ib qho tseem ceeb tyrosinase inhibitor, uas tuaj yeem cuam tshuam cov kev ua ntawm tyrosinase, thaiv cov synthesis ntawm dopa thiab dopaquinone, yog li inhibiting zus tau tej cov melanin, thiab tseem tuaj yeem txo cov pigmentation los ntawm ultraviolet rays, tab sis nws ruaj khov tsis zoo, nrog rau qee yam. photosensitivity.

Txoj kev tshawb no pom tias arbutin nrog ib qho concentration ntawm 3% muaj cov khoom zoo, tsis tshua muaj cytotoxicity, khaus thiab ua xua, thiab qhov siab tshaj ntawm nws cov concentration tsis tuaj yeem tshaj 7%.Ib tug siab concentration ntawm arbutin yuav decolorize ib txwm tawv nqaij.Nws cov khoom xyaw ntuj, glucopyranoside, muaj zog inhibitory nyhuv ntawm tib neeg tyrosinase dua arbutin, thiab hloov arbutin vim nws muaj txiaj ntsig zoo thiab ruaj khov.

2. Licorice Extract

Nws cov khoom xyaw nquag yog liquiritin, isoliquiritin thiab licorice flavonoids.Liquiritin ua rau daim tawv nqaij melanin sib npaug los ntawm dispersing lub aggregated melanin, thiab ua tiav cov nyhuv whitening;Lub luag haujlwm tseem ceeb ntawm licorice flavonoids yog inhibit qhov kev ua ntawm tyrosinase, DHICA oxidase thiab dopa pigment intermutase.

Cov kev tshawb fawb tau pom tias cov khoom kho mob ntawm daim tawv nqaij uas muaj licorice extract thiab papain tuaj yeem pab melasma thiab post-inflammatory hyperpigmentation, tsis tshua muaj kev phiv, thiab muaj qee yam .. thiab .. cov khoom.Nws cov concentration hauv cov khoom siv ntxuav hniav dawb yog 10% mus rau 40%, tab sis cov ntsiab lus ntawm cov khoom xyaw nquag hauv licorice tsis siab thiab kev ua kom huv yog nyuaj thiab kim.

3. Chuanxiong Extract

Cov kev tshawb fawb tau pom tias Chuanxiong extract tuaj yeem cuam tshuam cov haujlwm ntawm tyrosinase, uas qhia txog kev sib tw inhibitory nyhuv.Chuanqiong ointment tau tsim los ntawm cov qauv sib txawv ntawm cov emulsifiers sib txawv thiab cov thickeners sib txawv, kev tshawb fawb ntawm nws cov kev ua kom zoo nkauj thiab kev ua haujlwm tau pom tias 0.5% ~ 1.0% Chuanqiong ointment muaj cov yam ntxwv ntawm kev ruaj ntseg zoo, kev ua haujlwm siab thiab cov nyhuv whitening.

4. Rhodiola Rosea Extract

Salidroside thiab flavonoids yog nws cov khoom tseem ceeb, thiab salidroside tuaj yeem ua rau cov lipids thiab cell membranes los ntawm ultraviolet rays.Cov extract tuaj yeem cuam tshuam cov synthesis ntawm melanin thiab kev ua haujlwm ntawm tyrosinase, thiab yog tus neeg sawv cev zoo ntawm daim tawv nqaij.Txoj kev tshawb nrhiav pom tias 1% thiab 5% ntawm Rhodiola rosea extract tsis ua rau muaj kev cuam tshuam tsis zoo hauv tib neeg lub cev, thiab nws yog cov khoom siv tshuaj pleev ib ce uas muaj kev ruaj ntseg siab thiab muaj kev cia siab dav hauv kev siv tshuaj pleev ib ce.

5. Aloin

Nws yog ib qho qis molecular hnyav cog glycoprotein rho tawm los ntawm aloe vera.Nws tsuas yog inhibits qhov tsim ntawm dopaquinone los ntawm kev sib tw inhibiting qhov chaw dopa oxidation, thiab ua tiav tsis muaj kev sib tw inhibition los ntawm kev sib tw inhibiting tooj liab ions ntawm hydroxylase site.Kev ua haujlwm ntawm tyrosine hydroxylase.Tsis tas li ntawd, aloin tuaj yeem txo cov tawv nqaij blackening los ntawm ultraviolet rays, thiab muaj kev kho kom zoo ntawm daim tawv nqaij tom qab tshav ntuj.Aloin yog hydrophilic thiab tsis-cytotoxic.Kev sib xyaw aloin nrog arbutin tuaj yeem txhim kho cov nyhuv whitening.

6. Cog Polyphenols

Nws feem ntau muaj nyob rau hauv cov tawv ntoo, cov hauv paus hniav, nplooj thiab txiv hmab txiv ntoo ntawm cov nroj tsuag, thiab nws cov nyhuv whitening yog feem ntau cuam tshuam rau nws nqus ntawm ultraviolet rays, antioxidant tshem tawm dawb radicals, thiab inhibition ntawm tyrosinase thiab peroxidase kev ua ub no.Ellagic acid yog lub ntuj polyphenol muab rho tawm los ntawm pomegranate tev, tawv ntoo thiab ntau yam txiv hmab txiv ntoo thiab zaub.Nws tuaj yeem cuam tshuam qhov kev loj hlob ntawm melanocytes, inhibit qhov kev ua ntawm melanocyte tyrosinase, txo melanin synthesis, ultraviolet rays muaj zog nqus cov nyhuv, uas tuaj yeem ua lub luag haujlwm hauv kev tiv thaiv hnub ci lossis tshem tawm cov dawb radicals los ntawm kev nqus ultraviolet rays.Cog polyphenol yog ib yam khoom muaj txiaj ntsig, uas muaj kev cia siab dav rau kev txhim kho thiab kev siv tshuaj pleev ib ce.

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