Shikimic Acid yog dab tsi?

Shikimic acid (3,4,5-trihydroxy-1-cyclohexene-1-carboxylic acid) yog ib qho tshwm sim ntawm cov organic compound uas yog ib qho tseem ceeb nruab nrab ntawm biosynthesis ntawm lignin, aromatic amino acids (phenylalanine, tyrosine thiab tryptophan), thiab feem ntau. cog thiab microbial alkaloids.

Shikimic acid feem ntau yog siv los ua cov khoom pib rau kev lag luam synthesis ntawm cov tshuaj tiv thaiv kab mob oseltamivir (ib qho tshuaj tiv thaiv kab mob khaub thuas H5N1 siv los kho thiab tiv thaiv txhua hom kab mob khaub thuas). Cov synthesis ntawm (-)-zeylenone raws li Shikimic Acid tau tshaj tawm tias tau siv dav los ua tus neeg sawv cev rau kev kho mob qog noj ntshav. Cov ntaub ntawv muaj nyob rau ntawm synthesis ntawm monopalmitoyloxy Shikimic Acid, uas muaj anticoagulant kev ua si thiab muaj peev xwm txo tau cov ntshav coagulability thaum noj intramuscularly. Pab pawg tshawb fawb Suav tau tsim cov Shikimic Acid derivative, triacetyl Shikimic Acid, uas nthuav tawm cov tshuaj tiv thaiv coagulant thiab antithrombotic.

Tsis tas li ntawd, Shikimic Acid derivatives tau pom muaj kev txaus siab rau kev ua liaj ua teb ntau vim tias lawv siv ntau yam tshuaj tua kab mob thiab tshuaj tua kab mob vim tias lawv tuaj yeem thaiv txoj hauv kev Shikimic Acid hauv cov nroj tsuag thiab cov kab mob uas tsis muaj kev cuam tshuam rau cov tsiaj txhu.

Yog li, Shikimic Acid tuaj yeem siv los ua cov tshuaj reactant rau organic synthesis hauv ob qho tib si kev tshawb fawb thiab kev kho mob hauv cov organic chemistry thiab tshuaj, tshwj xeeb tshaj yog rau kev npaj ntau yam tshuaj.

Raws li cov khoom siv tshuaj tseem ceeb, shikimic acid tuaj yeem siv rau kev kho mob ntau yam kab mob:

1. Antibacterial thiab antitumor

Xyoo 1987, cov kws tshawb fawb Nyij Pooj tau pom tias cov analogue ntawm glyoxalase I inhibitor synthesized los ntawm methyl anthranilate muaj cov nyhuv inhibitory ntawm Hela cell kab thiab Escheri ascites carcinoma, tuaj yeem ua rau lub sijhawm muaj sia nyob ntawm cov nas uas muaj kab mob leukemia L1210, thiab cov tshuaj toxicity kuj tsawg, Nws cov nyhuv inhibitory feem ntau cuam tshuam nrog cov tshuaj tiv thaiv sulfur hydride. Xyoo 1988, Suav cov kws tshawb fawb muaj nyob rau xyoo 1988, Suav cov kws tshawb fawb tau tsim cov tshuaj shikimic acid derivative thiab ua pov thawj tias cov tshuaj no muaj cov nyhuv inhibiting leukemia hlwb L1210 hauv vitro.

2. Anti-thrombosis

Cov nyhuv ntawm shikimic acid thiab nws cov derivatives ntawm cov hlab plawv system yog qhia nyob rau hauv lub luag hauj lwm ntawm anti-thrombosis thiab inhibition ntawm platelet aggregation. Kev tshawb fawb qhia tau hais tias: shikimic acid muaj zog inhibitory nyhuv ntawm platelet aggregation tus nqi ntawm adenosine diphosphate-induced nruab nrab cerebral artery embolism qauv nas; txhaj tshuaj intramuscular thiab shikimic acid tuaj yeem ua rau cov ntshav txhaws lub sijhawm ntev ntawm cov nas.

3.Anti-cerebral ischemia

Shikimic acid thiab nws cov derivatives muaj cov txiaj ntsig ntawm kev txhim kho cerebral ischemia, feem ntau yog txo qhov ntim ntawm cerebral infarction tom qab focal cerebral ischemia hauv nas, txo cov qhab nia ua haujlwm neurological, txo cov qib ntawm cerebral edema, ua rau cov ntshav cerebral ntws hauv thaj tsam ischemic. thiab lwm yam ntsuas. Qee cov kev tshawb fawb tau pom tias nws cov derivatives tuaj yeem txo qhov degree ntawm erythrocyte aggregation thiab inhibit platelet aggregation tom qab cerebral ischemia, yog li pab txhawb cerebral microcirculation.