Shikimic Acid yog dab tsi?

Shikimic acid (3,4,5-trihydroxy-1-cyclohexene-1-carboxylic acid) yog ib qho organic compound uas tshwm sim los ntawm ntuj tsim uas yog ib qho tseem ceeb hauv kev tsim cov lignin, cov amino acids uas muaj ntxhiab (phenylalanine, tyrosine thiab tryptophan), thiab feem ntau cov nroj tsuag thiab cov kab mob alkaloids.

Shikimic acid feem ntau siv ua cov khoom siv pib rau kev tsim cov tshuaj tua kab mob oseltamivir (tshuaj tiv thaiv kab mob khaub thuas H5N1 siv los kho thiab tiv thaiv txhua hom kab mob khaub thuas). Kev tsim cov (-)-zeylenone raws li Shikimic Acid tau tshaj tawm tias siv dav ua tus neeg sawv cev rau kev kho mob qog noj ntshav. Cov ntaub ntawv muaj nyob rau ntawm kev tsim cov monopalmitoyloxy Shikimic Acid, uas muaj cov haujlwm anticoagulant thiab muaj peev xwm txo cov ntshav coagulability thaum muab intramuscularly. Ib pab pawg tshawb fawb Suav tau tsim cov Shikimic Acid derivative, triacetyl Shikimic Acid, uas muaj cov haujlwm anticoagulant thiab antithrombotic.

Tsis tas li ntawd xwb, cov tshuaj Shikimic Acid derivatives tau qhia txog kev txaus siab rau kev ua liaj ua teb vim tias ntau ntawm lawv siv ua cov tshuaj tua kab thiab cov tshuaj tua kab mob vim tias lawv tuaj yeem thaiv txoj kev Shikimic Acid hauv cov nroj tsuag thiab cov kab mob yam tsis muaj kev cuam tshuam tsis zoo rau cov tsiaj txhu.

Yog li, Shikimic Acid tuaj yeem siv los ua cov tshuaj reactant rau cov organic synthesis hauv ob qho tib si kev tshawb fawb yooj yim thiab kev siv kho mob hauv cov tshuaj organic thiab tshuaj, tshwj xeeb tshaj yog rau kev npaj ntau yam tshuaj.

Ua ib yam khoom siv tshuaj tseem ceeb, shikimic acid tuaj yeem siv rau kev kho mob ntawm ntau yam kab mob:

1. Tshuaj tua kab mob thiab tshuaj tiv thaiv qog nqaij hlav

Xyoo 1987, cov kws tshawb fawb Nyij Pooj tau pom tias cov tshuaj glyoxalase I inhibitor uas tsim los ntawm methyl anthranilate muaj cov nyhuv inhibitory rau Hela cell kab thiab Escheri ascites carcinoma, tuaj yeem ua kom lub sijhawm muaj sia nyob ntev dua ntawm cov nas uas tau txhaj tshuaj nrog leukemia cell L1210, thiab qhov tshuaj lom tsawg heev, nws cov nyhuv inhibitory feem ntau yog cuam tshuam nrog cov tshuaj sulfur hydride. Xyoo 1988, cov kws tshawb fawb Suav tau tsim cov tshuaj shikimic acid derivative thiab ua pov thawj tias cov tshuaj no muaj cov nyhuv ntawm kev tiv thaiv cov leukemia cell L1210 hauv vitro.

2. Tiv thaiv kev mob thrombosis

Cov nyhuv ntawm shikimic acid thiab nws cov derivatives rau lub plawv thiab cov hlab ntsha tau pom tias yog lub luag haujlwm ntawm kev tiv thaiv thrombosis thiab kev txwv tsis pub platelet aggregation. Kev tshawb fawb qhia tau hais tias: shikimic acid muaj cov nyhuv inhibitory rau platelet aggregation ntawm adenosine diphosphate-induced middle cerebral artery embolism qauv nas; kev txhaj tshuaj shikimic acid rau hauv cov hlab ntsha thiab cov leeg nqaij tuaj yeem ua rau lub sijhawm ntshav coagulation ntawm cov nas ntev dua.

3. Tiv thaiv kab mob cerebral ischemia

Shikimic acid thiab nws cov derivatives muaj cov nyhuv ntawm kev txhim kho cerebral ischemia, feem ntau yog nyob rau hauv kev txo qhov ntim ntawm cerebral infarction tom qab focal cerebral ischemia hauv nas, txo cov neurological muaj nuj nqi qhab nia, txo cov degree ntawm cerebral edema, ua rau cerebral ntshav ntws hauv thaj chaw ischemic thiab lwm yam qhia. Qee qhov kev tshawb fawb tau qhia tias nws cov derivatives tuaj yeem txo cov degree ntawm erythrocyte aggregation thiab inhibit platelet aggregation tom qab cerebral ischemia, yog li pab txhawb cerebral microcirculation.